目的 考察注射用氯諾昔康與鹽酸托烷司瓊注射液在0.9%氯化鈉注射液中的配伍穩(wěn)定性。方法 采用高效液相色譜法測(cè)定配伍溶液72 h內(nèi)氯諾昔康與鹽酸托烷司瓊的含量, 并觀察和檢測(cè)配伍液的外觀和pH值變化。結(jié)果 配伍溶液中氯諾昔康質(zhì)量分?jǐn)?shù)和pH值未見明顯變化, 但鹽酸托烷司瓊質(zhì)量分?jǐn)?shù)隨時(shí)間變化逐漸降低, 在2 h后質(zhì)量分?jǐn)?shù)低于60%, 且出現(xiàn)少量針狀沉淀。結(jié)論 在室溫條件下, 氯諾昔康與鹽酸托烷司瓊在0.9%氯化鈉注射液中不穩(wěn)定, 臨床不宜混合使用用于術(shù)后鎮(zhèn)痛。

Objective To study the stability of Lornoxicam for injection with Tropisetron Hydrochloride Injection in 0.9 % sodium chloride injection. Methods Concentrations of lornoxicam and tropisetron hydrochloride in compatible solution were determined by HPLC method. The appearance of compatible solution was observed within 72 h. The changes in pH value of compatible solution were determined. Results No significant differences were found in the pH value and contents of lornoxicam, but the contents of tropisetron hydrochloride declined below 60% of the initial concentration and appearance of precipitation after 2 h. Conclusion The mixture of Lornoxicam for injection with Tropisetron Hydrochloride Injection in 0.9% sodium chloride injection is instability, and clinical application for patient controlled analgesia should be avoided.

十堰市科學(xué)技術(shù)研究與開發(fā)計(jì)劃項(xiàng)目(14Y45)