目的 觀察遞法明片改善高度近視弱視患兒的臨床療效和安全性.方法 選取2012年10月—2013年10月深圳市眼科醫(yī)院收治的高度近視弱視患兒200例,隨機(jī)分為治療組和對(duì)照組,每組各100例.治療組口服遞法明片,1片/次,2次/d.對(duì)照組口服淀粉片1片/次,2次/d.兩組均連續(xù)用藥6個(gè)月.觀察兩組治療后3、6個(gè)月、隨訪6個(gè)月視力、屈光度、眼軸、角膜屈光力、角膜厚度等的變化.結(jié)果 治療6個(gè)月、隨訪6個(gè)月后,治療組患兒平均視力得到提高,與治療前比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05),對(duì)照組治療前后視力差異無統(tǒng)計(jì)學(xué)意義;治療6個(gè)月、隨訪6個(gè)月后,治療組視力優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05).治療6個(gè)月、隨訪6個(gè)月后,治療組屈光度、眼軸、角膜厚度均較治療前有很多改善,治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些指標(biāo)優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05).隨訪6個(gè)月后,對(duì)照組屈光度、眼軸、角膜厚度較治療前有所增長(zhǎng),治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05).結(jié)論 遞法明片能明顯改善高度近視弱視患兒的視力,降低屈光度、眼軸及角膜厚度,對(duì)高度近視弱視患兒有一定的療效.

Objective To explore the efficacy of Difaming Tablets in improvement of high myopia and amblyopia of children. Methods Patients (200 cases) with high myopia and amblyopia of children from October 2012 to October 2013 in the Ophthalmology Hospital of Shenzhen City were randomly divided into treatment (100 cases) and control (100 cases) groups. The patients in the treatment group were po administered with Difaming Tablets, one tablet/time, twice daily. The patients in the control group were po administered with Starch Tablets, one tablet/time, twice daily. The patients in the two groups were treated for six months. The changes of eyesight, diopter, eye axis, corneal refractive power, and corneal thickness in the two groups after the treatment of 3, 6 months, and followed up for 6 months were observed. Results The average eyesight in the treatment group was improved after the treatment of 6 months, and followed up for 6 months, and the differences were statistically significant before and after the treatment in the same group (P < 0.05). The eyesight in the control group was no statistically significant difference before and after the treatment. The eyesight in the treatment group was better than that in control group after the treatment of 6 months, and followed up for 6 months, with the significant difference between the two groups (P < 0.05). The diopter, eye axis, and corneal thickness in the treatment group were improved after the treatment of 6 months, and followed up for 6 months, and the differences were statistically significant before and after the treatment in the same group (P < 0.05). These indicators in the treatment group were better than those in the control group, with the significant difference between the two groups (P < 0.05). The diopter, eye axis, and corneal thickness in the control group were increased followed up for 6 months, and the differences were statistically significant before and after the treatment in the same group (P < 0.05). Conclusions Difaming Tablets can obviously improve the eyesight of high myopia and amblyopia of children, and can reduce the diopter, eye axis, and corneal thickness, which has the certain curative effect for high myopia and amblyopia of children.

深圳市科技計(jì)劃項(xiàng)目(201303101)