目的 探討哌拉西林鈉舒巴坦鈉持續(xù)靜滴治療重癥肺炎的臨床療效和安全性.方法 選取2012年6月—2014年2月內(nèi)蒙古林業(yè)總醫(yī)院收治的重癥肺炎90例,隨機(jī)分為治療組(46例)和對(duì)照組(44例).治療組患者首先給予注射用哌拉西林鈉舒巴坦鈉5.0 g溶入到200 mL生理鹽水中,1 h內(nèi)靜滴完,然后將注射用哌拉西林鈉舒巴坦鈉5.0 g溶入至20 mL生理鹽水中,將微量泵泵入速度調(diào)整為2 mL/h持續(xù)泵入,2次/d.對(duì)照組靜脈滴注注射用哌拉西林鈉舒巴坦鈉5.0 g溶入至200 mL生理鹽水中,1 h靜滴完,每8小時(shí)一次.兩組均持續(xù)治療3 d以上.比較兩組的臨床療效,同時(shí)比較兩組咳嗽消失時(shí)間、啰音消失時(shí)間、體溫恢復(fù)正常時(shí)間、白細(xì)胞恢復(fù)正常時(shí)間.結(jié)果 治療后,治療組和對(duì)照組的總有效率分別為80.44%、59.09%,兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05).治療組咳嗽消失時(shí)間、啰音消失時(shí)間、體溫恢復(fù)正常時(shí)間、白細(xì)胞恢復(fù)正常時(shí)間均顯著短于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05).結(jié)論 哌拉西林鈉舒巴坦鈉持續(xù)靜滴對(duì)重癥肺炎有較好的臨床療效,可縮短各觀察指標(biāo)的時(shí)間,值得臨床推廣應(yīng)用.

Objective To investigate the clinical effect of piperacillin and sulbactam sodium continuous iv drip in treatment of severe pneumonia. Methods Patients (90 cases) with severe pneumonia from June 2012 to February 2014 in the Inner Mongolia Forestry General Hospital were randomly divided into treatment (46 cases) and control (44 cases) groups. The patients in the treatment group were iv administered with Piperacillin and Sulbactam Sodium for injection 5.0 g adding into 200 mL 0.9% saline solution in 1 h, then diluted with 20 mL physiological saline continuous iv pump infusion, and the pumping speed was adjusted at 2 mL/h, twice daily. The patients in the control group were iv administered with Piperacillin and Sulbactam Sodium for injection 5.0 g adding into 200 mL 0.9% saline solution in 1 h, every 8 h/time. The patients in the two groups were treated for more than 3 d. After the treatment, the efficacy was evaluated, while the time of cough disappeared, rale disappear time, body temperature returned to normal time, and white blood cells back to normal time in two groups were compared. Results The efficacies in the treatment and control groups were 80.44% and 59.09%, respectively, and there were differences between two groups (P < 0.05). The time of cough disappeared, rale disappear time, body temperature returned to normal time, and white blood cells back to normal time in treatment group were shorter than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Piperacillin and sulbactam sodium continuous iv drip has good clinical effect in treatment of severe pneumonia, and can shorten the time of observational indexes, which is worth of clinical promotion.