白屈菜堿是白屈菜Chelidonium majus的主要活性成分之一,屬于苯并菲啶類生物堿,現(xiàn)作為止痛藥應(yīng)用于臨床.隨著對(duì)白屈菜堿藥理作用的深入研究發(fā)現(xiàn),其具有抗腫瘤、鎮(zhèn)痛、抗菌、解痙等多種藥理作用,且其抗腫瘤作用越來(lái)越受到關(guān)注.對(duì)近年來(lái)白屈菜堿藥理作用的國(guó)內(nèi)外研究進(jìn)展做以綜述,為其進(jìn)一步研究與應(yīng)用提供理論依據(jù).

Chelidonine, a benzophen anthridine alkaloid, is one of the main effective constituents of Chelidonium majus, which is applied as a painkiller in clinical treatment. The further studies on the pharmacological activities in recent years have demonstrated that chelidonine plays a role in antitumor, analgesic, antibacterial, spasmolysis activities, etc. And the antitumor activity is paid more and more attention. In this paper, research progress on pharmacological activities and mechanisms of chelidonine home and abroad in recent years are reviewed, which could provide a theoretical basis for the further study and application of C. majus.

國(guó)家自然科學(xué)基金資助項(xiàng)目(81102858);中國(guó)博士后科學(xué)基金資助項(xiàng)目(2013M531060);黑龍江省自然科學(xué)基金資助項(xiàng)目(D200817);黑龍江省博士后科研基金項(xiàng)目(LBH-Z11103);黑龍江省教育廳骨干教師項(xiàng)目(1154G35)