目的 探討復(fù)方甘草酸苷注射劑致過敏性休克的臨床特點(diǎn)及規(guī)律,為合理用藥提供參考.方法 檢索中國期刊全文數(shù)據(jù)庫(CNKI)、中文科技期刊全文數(shù)據(jù)庫(維普)、萬方數(shù)字化期刊全文庫等數(shù)據(jù)庫,對涉及病例的文獻(xiàn)進(jìn)行分析和討論.結(jié)果 復(fù)方甘草酸苷注射劑致過敏性休克17例,其發(fā)生與患者年齡、性別無明顯關(guān)系;其中15例(88.2%)發(fā)生在首次給藥后的20 min內(nèi),臨床表現(xiàn)及解救方法與其他過敏性休克無明顯差異.經(jīng)積極的抗過敏性休克搶救,全部病例恢復(fù)正常,無死亡病例.醫(yī)務(wù)人員對患者用藥初期出現(xiàn)的不良反應(yīng)不夠重視是發(fā)生過敏性休克的安全隱患.結(jié)論 復(fù)方甘草酸苷注射劑致過敏性休克并不罕見,醫(yī)務(wù)人員應(yīng)予以重視.

Objective To explore the clinical characteristics and rules of anaphylactic shock induced by Compound Glycyrrhizin Injection, and to provide the references for the rational use of drugs in clinic. Methods China Journal Full-text Database (CNKI), Chinese Science and Technology Journal Full-text Database (VIP), Wangfang Database, etc were retrieved, and the literature involving cases were analyzed and discussed. Results There were 17 anaphylactic shock cases caused by Compound Glycyrrhizin Injection, and they had no obvious relationship with age and gender. Fifteen cases (88.2%) occured in the medication within 20 min after iv infusion. There was no significant difference in clinical manifestations and rescue compared with other anaphylactic shock. After active anti-anaphylactic shock rescue, all patients returned to normal with no deaths. It was the security risk to anaphylactic shock that medical staff didn't pay attention to ADR at the initial treatment stage. Conclusion Anaphylactic shock induced by Compound Glycyrrhizin Injection is not rare, and clinical medical workers should pay attention to it.