目的 考察注射用氯諾昔康與頭孢甲肟在0.9%氯化鈉注射液中的配伍穩(wěn)定性，為臨床合理用藥提供理論依據(jù)。方法 在室溫條件下，采用HPLC法測(cè)定8 h內(nèi)配伍溶液中氯諾昔康、頭孢甲肟的變化，并觀察和檢測(cè)外觀、pH值變化，結(jié)果 配伍溶液在8 h內(nèi)氯諾昔康的質(zhì)量分?jǐn)?shù)未見明顯變化，但頭孢甲肟質(zhì)量分?jǐn)?shù)不斷下降，8 h后為95.3%。pH值隨時(shí)間變化逐漸降低，溶液顏色隨時(shí)間變化逐漸加深。結(jié)論 在室溫條件下，注射用氯諾昔康與注射用頭孢甲肟在0.9%氯化鈉注射液中2 h內(nèi)保持穩(wěn)定，可配伍使用。

Objective To study the stability of compatibility of Lornoxicam for injection and Cefmenoxime for injection in 0.9% sodium chloride injection to supply the evidence for clinical rational administration. Methods HPLC method was carried out to study the content change of cefmenoxime and lornoxicam in 0.9% sodium chloride injection under the room temperature. The appearance of the solution was observed and its pH value was determined. Results No significant difference was found in the content of lornoxicam within 8 h, but the contents of cefmenoxime declined with 95.3% of the initial concentration during 8 h. The pH value decreased and the color gradually deepened as time went on. Conclusion The mixture of cefmenoxime with lornoxicam in 0.9% sodium chloride injection can be used under the room temperature, but must be injected within 2 h.

十堰市科學(xué)技術(shù)研究與開發(fā)計(jì)劃項(xiàng)目（14Y59，14Y45）