目的 探討聚甲酚磺醛聯(lián)合重組人干擾素α-2a在微波治療宮頸炎中的臨床療效。方法 選取2011年1月-2014年1月在三亞市吉陽鎮(zhèn)衛(wèi)生院治療的宮頸炎患者80例，隨機(jī)分為治療組（40例）和對(duì)照組（40例）。對(duì)照組患者采用微波治療，術(shù)后第2天起應(yīng)用重組人干擾素α-2a治療，陰道上藥，1粒/次，1次/d。治療組于術(shù)后第2天給予浸有聚甲酚磺醛的消毒紗布敷于宮頸表面，1次/d，其余同對(duì)照組。兩組均連續(xù)治療6 d。觀察兩組患者的臨床療效，同時(shí)比較兩組患者治療前后銅藍(lán)蛋白活力、IL-2水平的變化。結(jié)果 治療組和對(duì)照組的總有效率分別為100.0%、97.5%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者銅藍(lán)蛋白活力和IL-2水平均較治療前顯著降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組這兩項(xiàng)檢測(cè)指標(biāo)均顯著低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 聚甲酚磺醛聯(lián)合重組人干擾素α-2a在微波治療宮頸炎中有較好的臨床療效，可以更好的改善臨床癥狀和降低炎癥反應(yīng)，值得臨床推廣應(yīng)用。

Objective To observe the clinical efficacy of policresulen combined with polyethylene glycol interferon α-2a in the microwave treatment of cervicitis. Methods Patients (80 cases) with cervicitis in Jiyang Township Health Centers of Sanya City from January 2011 to January 2014 were randomly divided into treatment (40 cases) and control (40 cases) groups. The patients in the control group were treated by microwave, and they were given polyethylene glycol interferon α-2a in vagina from the second day after the microwave treatment, 1 grain/time, once daily. The patients in the treatment group were treated with sterile gauze leaching with policresulen on the surface of the cervix, once daily, and other treatment was the same as the control group. The total clinical efficacy was observed, including the changes of copper blue protein activity and IL-2 level in the two groups before and after the treatments were compared. Results The total effective rates of patients in the treatment and control groups were 100.0% and 97.5%, respectively, with the significant difference between the two groups (P < 0.05). After the treatment, copper blue protein activity and IL-2 level were lower than those before the treatment in the two groups, and the differences were statistically significant in the same group before and after the treatment (P < 0.05). After the treatment, the two measurement indexes in the treatment group were significantly lower than those in the control group, with the significant difference between the two groups (P < 0.05). Conclusion Policresulen combined with polyethylene glycol interferon α-2a has a good clinical efficacy in the microwave treatment of cervicitis, and can better improve the clinical symptoms and reduce inflammation, which is worthy of clinical popularization and application.

國家自然科學(xué)基金資助項(xiàng)目（30872743）