目的 探討銀鋅霜治療Ⅱ度燒傷患者污染創(chuàng)面的臨床療效。方法 選取2011年3月-2014年2月來(lái)上海交通大學(xué)醫(yī)學(xué)院附屬第三人民醫(yī)院就診的Ⅱ度燒傷患者102例，隨機(jī)分為治療組和對(duì)照組，每組51例。對(duì)所有患者進(jìn)行及時(shí)的清創(chuàng)及創(chuàng)口清洗處理，并給予常規(guī)補(bǔ)液、鎮(zhèn)痛等處理。治療組加用銀鋅霜進(jìn)行外用涂敷治療，1次/d。對(duì)照組加用濕潤(rùn)燒傷膏外用涂敷，3次/d。每次均涂抹外用藥物適量于創(chuàng)面并進(jìn)行包扎處理，并依據(jù)患者病情決定藥物使用時(shí)間。比較兩組患者的換藥次數(shù)、愈合時(shí)間、抗生素使用時(shí)間、住院時(shí)間、創(chuàng)面愈合情況等。結(jié)果 治療組患者的換藥次數(shù)、愈合時(shí)間、抗生素應(yīng)用時(shí)間及住院時(shí)間均明顯短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療4 d、1周、2周后治療組淺Ⅱ度和深Ⅱ度燒傷患者的創(chuàng)口愈合率均明顯高于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療過(guò)程中兩組患者均出現(xiàn)創(chuàng)面加深、創(chuàng)面膿毒癥、創(chuàng)面異味等不良事件，治療組創(chuàng)面異味的發(fā)生率明顯低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療組無(wú)高熱發(fā)生，對(duì)照組高熱的發(fā)生率為7.84%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 銀鋅霜對(duì)Ⅱ度燒傷患者污染創(chuàng)面有較好的臨床療效，可明顯改善患者創(chuàng)面愈合狀況，值得臨床推廣應(yīng)用。

Objective To explore the efficacy of Silver-zinc Cream in the treatment of degree Ⅱ burn with contamination wounds. Methods The patients suffered form degree Ⅱ burn (102 cases) in No.3 People Hospital Affiliated to Shanghai Jiaotong University School of Medicine from March 2011 to February 2014 were randomly divided into treatment and control groups, and there were 51 cases in each group. All the patients were given debridement and wound cleaning processing, and were given regular rehydration and analgesic treatment. The patients in the treatment group used Silver-zinc Cream for external coating treatment, once daily; The patients in the control group used Moist Burn Cream for external coating treatment, 3 times daily. The drugs were applied right amount thickness in the treatment of wound by bandaged and the drug usage time was decided according to the condition of patients. Switching frequency, time of healing, antibiotic usage, hospital stay, and situation of wound healing were compared. Results Switching frequency, time of healing, antibiotic usage, hospital stay, and situation of wound healing in the treatment group are significantly shorter than those in the control group, with the significant difference between the two groups (P < 0.05). Burn wound healing rate was significant difference between the two groups (P < 0.05). Burn wound healing rate of shallow degree Ⅱ and deep degree Ⅱ in the treatment group for 4 d, 1 week, and 2 weeks after the treatment were significantly higher than those in the control group, with the significant difference between the two groups (P < 0.05). Adverse events of wound deepened, sepsis, and wound odor were happened in the two groups. Incidence of wound odor in the treatment group was obviously lower than that in the control group, with the significant difference between the two groups (P < 0.05). There was no fever in the treatment group, while the incidence of fever in the control group was 7.84%, with the significant difference between the two groups (P < 0.05). Conclusion Silver-zinc Cream has a good clinical efficacy in the treatment of degree Ⅱ burn with contamination wounds, and could obviously improve the condition of wound healing, which is worthy of clinical application.

國(guó)家自然科學(xué)基金資助項(xiàng)目（81071567）