目的 觀察血三七水煎液對(duì)局灶性腦缺血大鼠血液流變學(xué)的影響。方法 除對(duì)照組外，其余大鼠均采用結(jié)扎頸外動(dòng)脈建立大鼠大腦中動(dòng)脈局灶性腦缺血模型，造模成功的大鼠隨機(jī)分為模型組，假手術(shù)組，血三七水煎液高、中、低劑量（15、10、5 g/kg）組和腦心通膠囊組（0.5 g/kg），1次/d，給藥21 d后取血，測(cè)定全血黏度、全血還原黏度、紅細(xì)胞聚集指數(shù)、紅細(xì)胞變形指數(shù)、紅細(xì)胞剛性指數(shù)和紅細(xì)胞電泳指數(shù)等血液流變學(xué)指標(biāo)。結(jié)果 與模型組比較，各給藥組的全血黏度、全血還原黏度、紅細(xì)胞聚集指數(shù)、紅細(xì)胞變形指數(shù)、紅細(xì)胞剛性指數(shù)和紅細(xì)胞電泳指數(shù)均不同程度地降低，且血三七水煎液高、中劑量組的作用效果與腦心通膠囊組相當(dāng)。結(jié)論 血三七水煎液可以改善局灶性腦缺血大鼠血液流變學(xué)的相關(guān)指標(biāo)。

Objective To observe the effects of Polygonum amplexicaule var. sinense water decoction (PAWD) on hemorheology in rats after focal cerebral ischemia. Methods Except the control group, all the rats in the other groups were performed to induce the middle cerebral artery occlusion model via ligation of external carotid artery. All the model rats were randomly divided into model, Sham, high-, mid-, and low-dose (15, 10, and 5 g/kg) PAWD, and Naoxintong Capsule (0.5 g/kg) groups, and administered once a day. The blood samples were taken after 21 d administration, and the whole blood viscosity, reductive viscosity, red cell assembling index, erythrocyte deformation index, erythrocyet index of rigidity, and erythrocyte electrophoresis index were determined. Results Compared with the model group, the whole blood viscosity, reductive viscosity, red cell assembling index, erythrocyte deformation index, erythrocyet index of rigidity, and erythrocyte electrophoresis index in each treatment group had descended to some extent. The pharmacological actions of high- and mid-dose PAWD groups were equal to those of Naoxintong Capsule group. Conclusion PAWD could improve the hemorheology in rats after focal cerebral ischemia, which is worthy of research and development.

湖南省中醫(yī)藥管理局課題（2013139）