目的 觀察注射用頭孢唑林鈉和五水頭孢唑林鈉在6種溶媒中的穩(wěn)定性，為臨床合理配置使用頭孢唑林鈉提供依據(jù)。方法 將注射用頭孢唑林鈉分別加入0.9%氯化鈉注射液、5%葡萄糖注射液、乳酸鈉林格注射液、木糖醇注射液、轉(zhuǎn)化糖電解質(zhì)注射液、果糖注射液，在25、40℃下觀察溶液6 h 內(nèi)的外觀，測定pH 值，用高效液相色譜法測定頭孢唑林鈉在溶媒中的質(zhì)量分?jǐn)?shù)。結(jié)果 25℃和40℃下6 h內(nèi)頭孢唑林鈉在6種溶媒中的質(zhì)量分?jǐn)?shù)均大于95%，配制液pH值、外觀無明顯變化；在40℃下6 h后頭孢唑林鈉質(zhì)量分?jǐn)?shù)小于90%，并隨時間延長呈下降趨勢。配制液pH值也有所下降。結(jié)論 注射用頭孢唑林鈉在0.9%氯化鈉注射液、5%葡萄糖注射液、乳酸鈉林格注射液、木糖醇注射液、果糖注射液、轉(zhuǎn)化糖電解質(zhì)注射液中40、25℃下6 h內(nèi)是穩(wěn)定的。注射用頭孢唑林鈉加入上述溶媒后應(yīng)在6 h內(nèi)輸注完畢，高溫環(huán)境下應(yīng)現(xiàn)配現(xiàn)用。

Objective To study the stability of Cefazolin Sodium for injection and Pentahydrate Cefazolin Sodium for injection in six kinds of solvents, and to provide evidence for clinical rational use of cefazolin sodium. Methods Cefazolin Sodium for injection was added in 0.9% Sodium Chloride Injection, 5% Glucose Injection, Sodium Lactate Ringer's Injection, Xylitol Injection, Multiple Electrolytic and Invert Sugar Injection, and Fructose Injection. The appearance, pH values, and contents of cefazolin sodium were observed within 6 h at 25 and 40℃. The contents of cefazolin sodium in Cefazolin Sodium for injection samples in the media were obtained by HPLC methods. Results The contents of cefazolin sodium in six kinds of solvents at 25 and 40℃ during 6 h were above 95%. There were no significant changes in appearance and pH value during 6 h. At 40℃ content of cefazolin sodium was below 90% after 6 h and decreased with the change of time. The pH value of configuration solution also increased. Conclusion Cefazolin Sodium for Injection in 0.9% Sodium Chloride Injection, 5% Glucose Injection, Sodium Lactate Ringer's Injection, Xylitol Injection, Fructose Injection, and Multiple Electrolytic and Invert Sugar Injection at 40 and 25℃ during 6 h is stable. The solvents with Cefazolin Sodium for injection should be infused within 6 h, and they should be prepared when using as the environment is in the condition of high temperature.

中國中日科技交流協(xié)會科研課題（2013-2015年）