目的 觀察炎琥寧聯(lián)合更昔洛韋治療小兒輪狀病毒感染性腹瀉的療效。方法 選取2010年5月-2013年12月延安市人民醫(yī)院確診的小兒輪狀病毒感染性腹瀉患兒235例，隨機分為治療組（120例）和對照組（115例）。對照組在常規(guī)治療基礎上靜脈滴注更昔洛韋注射液，5 mg/（kg·d）加入5%葡萄糖注射液150 mL，15滴/min，1次/d。治療組靜脈滴注炎琥寧注射液，10 mg/（kg·d）加入250 mL葡萄糖注射液中，1次/d；其他治療同對照組。兩組患者均持續(xù)治療5 d。治療結束后比較兩組患兒臨床治療總有效率、癥狀消失時間、人輪狀病毒抗原（RV-Ag）轉陰率及不良反應情況。結果 治療后，治療組和對照組的總有效率分別為91.7%、71.3%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療組體溫恢復時間、嘔吐消失時間、腹瀉改善時間、住院時間均明顯短于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療3 d后，治療組患兒大便RV-Ag轉陰率為85.8%，對照組轉陰率為71.3%，兩組比較差異有統(tǒng)計學意義（P<0.05）；治療5 d后，治療組轉陰率為100.0%，對照組轉陰率為91.3%，兩組比較差異有統(tǒng)計學意義（P<0.05）。兩組均未發(fā)生嚴重不良反應。結論 炎琥寧聯(lián)合更昔洛韋治療小兒輪狀病毒感染性腹瀉有較好的臨床療效，不良反應輕微，值得臨床推廣應用。

Objective To explore the curative effect of Yanhuning combined with ganciclovir in the treatment of infantile rotavirus infection diarrhea. Methods Patients (235 cases) with rotavirus infection diarrhea for the treatment in the People's Hospital of Yan'an City from May 2010 to December 2013 were randomly divided into treatment (120 cases) and control (115 cases) groups. On the basis of conventional treatment, the patients in the control group were treated with Ganciclovir Injection 5 mg/(kg·d) by adding into 5% Glucose Injection 150 mL, 15 drops/min, once daily. The patients in the treatment group were treated with Yanhuning Injection 10 mg/(kg·d) by adding in Glucose Injection 250 mL, once daily, and other treatment was the same as the control group. The patients in both groups were treated for 5 d. After treatment, the clinical effective rate, symptoms disappearing time, RV-Ag overcast rate, and adverse reaction in two groups were compared. Results After treatment, the efficacies on the patients in the treatment and control groups were 91.7% and 71.3%, with significant difference between the two groups (P < 0.05). The body temperature recovery time, vomiting disappearing time, diarrhea improving time, and time in the hospital of the treatment group were significantly shorter than those in the control group, and there was the significant difference between the two groups (P < 0.05). After 3 d treatment, the RV-Ag overcast rates in the treatment and control groups were 85.8% and 71.3%, with significant difference between the two groups (P < 0.05). After 5 d treatment, the RV-Ag overcast rate in the treatment and control groups were 100.0% and 91.3%, with significant difference between the two groups (P < 0.05). There was no serious adverse reaction in the two groups. Conclusion Yanhuning combined with ganciclovir has a good clinical efficacy in the treatment of infantile rotavirus infection diarrhea with slight adverse reactions, which is worthy of clinical application.

陜西省教育廳課題（09JK818）