目的 探討多索茶堿片聯(lián)合噻托溴銨粉霧劑治療煤工塵肺的療效。方法 將北京京煤集團(tuán)總醫(yī)院2011年11月-2012年10月收治的90例煤工塵肺患者隨機(jī)分為治療組和對(duì)照組，各45例，對(duì)照組在常規(guī)治療基礎(chǔ)上口服多索茶堿片，0.2 g/次，2次/d；治療組聯(lián)合使用噻托溴銨粉霧劑，18 μg/d，吸入給藥；兩組均治療4周，比較兩組患者治療前后臨床癥狀及肺功能情況。結(jié)果 治療后治療組臨床癥狀顯著優(yōu)于對(duì)照組，兩組相比差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療3個(gè)月后，治療組各肺功能指標(biāo)明顯改善，與治療前相比差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），且治療3、6個(gè)月后治療組肺功能指標(biāo)顯著優(yōu)于同時(shí)段對(duì)照組，兩組間相比差異也有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 多索茶堿片聯(lián)合噻托溴銨粉霧劑能夠改善煤工塵肺患者臨床癥狀，提高患者肺功能，療效確切，不良反應(yīng)少，值得臨床推廣應(yīng)用。

Objective To explore the effects of Doxofylline Tablets combined with Tiotropium Bromide Powder for inhalation on pulmonary function of coal workers' pneumoconiosis. Methods Patients (90 cases) with coal workers' pneumoconiosis of Beijing Jingmei Group General Hospital from November 2011 to November 2012 were randomly divided into treatment group and control groups (45 cases in each group). On the basis of conventional treatment, the patients in the control group were po administered with Doxofylline Tablets 0.2 g once, twice daily. While the patients in the treatment group were administered combined with Tiotropium Bromide Powder Spray 18 μg daily. The patients in the both groups were treated for 4 weeks. The clinical symptoms and pulmonary function were compared for the patients between the two groups. Results After the treatment, the clinical symptoms in the treatment group improved more significantly than those in the control group, with statistically significant difference between the two groups (P < 0.05). After 3 months of the treatment, the pulmonary function of the patients in the treatment group were improved significantly, and the difference was statistically significant (P < 0.05). After the treatment for 3 and 6 months, the lung function index was significantly higher than that of the patients in the control group at the same time, and there were significant differences between the two groups (P< 0.05). Conclusion Doxofylline Tablets combined with Tiotropium Bromide Powder for Inhalation can improve the clinical symptoms in the patients with coal workers' pneumoconiosis, and pulmonary function with less adverse reaction. It is worthy of clinical application.