目的 了解邯鄲市各醫(yī)院使用的他汀類藥物不良反應(yīng)（ADR）發(fā)生情況，為臨床合理用藥提供依據(jù)。方法 對邯鄲市藥品不良反應(yīng)監(jiān)測機構(gòu)上報的2001—2013年他汀類藥物不良反應(yīng)登記資料進行回顧性統(tǒng)計分析。結(jié)果 ADR累及多個系統(tǒng)–器官，主要包括肝膽、胃腸、肌肉骨骼及神經(jīng)系統(tǒng)，其他系統(tǒng)相對少見。嚴(yán)重不良反應(yīng)以肝損害最常見；不同他汀類ADR有所差異，辛伐他汀主要累及肌肉骨骼、胃腸系統(tǒng)和肝膽系統(tǒng)，阿托伐他汀主要累及肝膽和神經(jīng)系統(tǒng)，氟伐他汀主要累及胃腸系統(tǒng)。結(jié)論 目前在臨床上應(yīng)用的他汀類藥物在常規(guī)劑量范圍內(nèi)均有ADR發(fā)生，應(yīng)規(guī)范降脂用藥劑量和時限，減少不良反應(yīng)發(fā)生。

Objective To analyze the adverse drug reaction (ADR) induced by statins in Handan City, and to provide the reference for clinical rational drug usage. Methods ADRs of statins reported by Handan ADR monitoring agencies from 2001 to 2013 were retrospectively analyzed. Results ADRs involved multiple system organs including hepatobiliary system, gastrointestinal system, muscles, bones, and nervous system, while the other systems were relatively uncommon. The serious ADRs frequently involved liver dysfunction. Different kinds of statins could induce different ADR. Simvastatin mainly involved musculoskeletal, gastrointestinal, and hepatobiliary systems, and at the same time, atorvastatin mainly involved the hepatobiliary and nervous systems. Fluorine mainly affected the gastrointestinal system. Conclusion At present, ADR can occur in all statins at regular dosage range in the clinical application, and lipid-lowering drugs should be strictly regulated by dosage and time-limit, so as to reduce the incidence of ADR.