目的 采用多種實(shí)驗(yàn)?zāi)Ｐ驮u(píng)價(jià)川芎救心滴丸對(duì)大鼠和小鼠實(shí)驗(yàn)性心肌缺血的保護(hù)作用。方法 采用結(jié)扎大鼠冠狀動(dòng)脈前降支引起急性實(shí)驗(yàn)性心肌缺血模型，觀察川芎救心滴丸的抗心肌缺血作用；采用靜脈注射高分子右旋糖酐致大鼠高黏滯血癥模型，觀察川芎救心滴丸的活血作用；采用小鼠注射異丙腎上腺素實(shí)驗(yàn)?zāi)Ｐ?，觀察川芎救心滴丸的耐缺氧作用。結(jié)果 與模型組比較，大鼠ig川芎救心滴丸0.32、0.64 g/kg劑量組能明顯抑制因冠狀動(dòng)脈前降支結(jié)扎引起標(biāo)準(zhǔn)Ⅱ?qū)?lián)心電圖ST段的升高，明顯縮小心肌梗死范圍；0.16、0.32、0.64 g/kg劑量組明顯抑制高分子右旋糖酐所致高黏滯血癥大鼠全血黏度的升高；與模型組比較，小鼠ig川芎救心滴丸0.46、0.92 g/kg劑量組明顯延長(zhǎng)注射異丙腎上腺素后小鼠常壓缺氧條件下的存活時(shí)間。結(jié)論 川芎救心滴丸具有明顯的活血、耐缺氧作用，對(duì)實(shí)驗(yàn)性心肌缺血有明顯的保護(hù)作用。

Objective To evaluate the protective effects of Chuanxiong Jiuxin Dropping Pill on experimental myocardial ischemia in rats and mice using various experimental model. Methods The anti-myocardial ischemia effects of Chuanxiong Jiuxin Dropping Pill were observed using acute experimental myocardial ischemia model rats caused by coronary artery ligation of anterior descending branch. The effects of Chuanxiong Jiuxin Dropping Pill on invigorating the circulation of blood were observed using high blood viscosity model rats induced by intravenous injection of high molecular Dextran. The effects of Chuanxiong Jiuxin Dropping Pill on hypoxia tolerance were observed using the injection of isoproterenol experimental model. Results There was significant difference between the model group and 0.32, 0.64 g/kg Chuanxiong Jiuxin Dropping Pill groups in inhibiting the increase caused by the anterior descending coronary artery ligation induced standard Ⅱ-lead electrocardiograph ST segment and reducing myocardial infarct size. The 0.16, 0.32, and 0.64 g/kg Chuanxiong Jiuxin Dropping Pill groups could significantly inhibit the increase of whole blood viscosity caused by high blood viscosity model induced by high molecular Dextran. There was significant difference between the model group and 0.46, 0.92 g/kg Chuanxiong Jiuxin Dropping Pill groups in prolonging the survival time of mice under normobaric hypoxia condition after the injection of isoprenaline. Conclusion Chuanxiong Jiuxin Dropping Pill has the obvious effect on invigorating the circulation of blood and hypoxia tolerance, and has a protective effect on experimental myocardial ischemia.