目的 研究天舒滴丸對急性血瘀模型大鼠血液流變學、血小板聚集及血栓形成的影響。方法 SD大鼠隨機分為對照組、模型組、天舒膠囊（4.0 g/kg）組、天舒滴丸（1.0、2.0、4.0 g/kg）組，ig給藥3 d后，采用腎上腺素配合冰浴制備大鼠急性血瘀模型，分別測定全血黏度，血漿黏度，紅細胞壓積，血沉，體外形成血栓的長度、濕質量、干質量，血小板聚集率等指標。結果 天舒滴丸能明顯降低急性血瘀模型大鼠全血和血漿黏度，明顯降低血栓長度、血栓濕質量和干質量，抑制模型大鼠血小板聚集率的升高。結論 天舒滴丸能夠改善急性血瘀模型大鼠血液流變性，抑制血小板聚集及血栓形成。

Objective To study the effects of Tianshu Dropping Pill on hemorheology, thrombosis, and platelet aggregation in acute blood stasis model rats. Methods The mice were divided into six groups such as control, model, Tianshu Capsule (4.0 g/kg), and Tianshu Dropping Pill (1.0, 2.0, and 4.0 g/kg) groups. After ig administration for 3 d, the acute blood stasis rat model was established by sc injection of adrenaline hydrochloride and being socked in ice-water. Viscosity of blood and plasma, erythrocyte sedimentation, hematocrit, rates of platelet aggregation, and wet weight, length, and dry weight of thrombosis formed in vitro were determined. Results Tianshu Dropping Pill could not only significantly decrease the viscosity of whole blood and plasma, but also remarkably inhibit the rates of platelet aggregation and reduce the wet weight, length, and dry weight of thrombosis. Conclusion Tianshu Dropping Pill can obviously ameliorate the hemorheology and inhibit platelet aggregation and thrombosis in acute blood stasis rats.

國家重大新藥創(chuàng)制項目（2012ZX09201201-002）