目的 對夏黃顆粒提取浸膏粉進(jìn)行處方前粉體學(xué)和穩(wěn)定性研究，為設(shè)計優(yōu)良的顆粒制劑處方提供參考。方法 考察夏黃顆粒提取浸膏粉的主要粉體學(xué)參數(shù)，如堆密度、休止角、溶化性、pH值、吸濕性、臨界相對濕度。以主要活性成分蘆薈苷為指標(biāo)，考察高溫、高濕和強(qiáng)光照射的影響。結(jié)果 夏黃顆粒提取浸膏粉流動性較差，休止角大于45°，水溶性較好，呈弱酸性，臨界相對濕度為72%；不耐高溫，易吸濕，不耐光照。結(jié)論 夏黃顆粒提取浸膏粉應(yīng)在密封、避光、干燥處儲存。

Objective To evaluate the preformulation studies, such as micromeritic and stability studies on Xiahuang Granule extracts and to provide a reference for the design of fine particle formulation of design. Methods Powder micromeritics major parameters of Xiahuang Granule extracts, such as bulk density, angle of repose, dissolve resistance, pH value, moisture absorption, and critical relative humidity were studied. Aloin as the main active ingredient in the prescription was determined to compare the effects of high temperature, high humidity, and strong light on Xiahuang Granule extract, such as bulk density, angle of repose, dissolve resistance, pH value, moisture absorption, and critical relative humidity were studied. Results Xiahuang Granule extracts had the good water solubility with repose angle greater than 45 degrees, but poor mobility and weak acidity. The critical relative moisture of it was72%. Xiahuang Granule extracts had not been resistant to high temperature, moisture absorption, and lightfast properties. Conclusion The powder of Xiahuang Granule extracts should be stored up on sealed, dark, and dry place.

國家“十二五”科技支撐計劃項目（2011BA107B01）；天津市科技計劃項目（13ZCZDSY00200）