目的 對比Parteck? M200、M100直壓甘露醇和直壓甘露醇C、D 4種不同型號甘露醇對吲達帕胺直接壓片的影響，為直接壓片選擇輔料提供參考。方法 以吲達帕胺為模型藥物考察粉體學，采用直壓工藝與4種甘露醇壓片后，進行片劑質(zhì)量分析比較。結(jié)果 4種型號甘露醇對模型藥物均有很好的容納性，Parteck? M200、M100直壓甘露醇與吲達帕胺的相容性及混合壓片后的溶出度較好。結(jié)論 甘露醇是良好的直壓工藝的填充劑，不同型號的甘露醇與模型藥物混合有一定的差異。

Objective To compare the effects of four different types of mannitol, such as Parteck? M200, M100, and mannitol C and D on indapamide for direct compression tableting and to provide the reference for the selection of production excipients for direct compression tableting. Methods The powder properties of four kinds of mannitol were compared. Using four kinds of mannitol to trial-produce Indapamide Tablets, the differences of the four kinds of mannitol were compared through analysis on the quality of tablets. Results All the four types of mannitol had a good containment on model drugs; Parteck? M200 and M100 had a better compatibility of indapamide and a higher dissolution of its tablets. Conclusion Mannitol is a good filler for direct pressure process, and different types of mannitol have the certain influence on the content uniformity of model drugs.