藥用輔料是藥物制劑的基礎(chǔ)材料和重要組成部分，在制劑劑型和生產(chǎn)中起關(guān)鍵作用。隨著藥用輔料生產(chǎn)技術(shù)的迅速發(fā)展，具有低吸濕性、對(duì)原輔料和人體惰性、優(yōu)異的壓片性能與口感良好的優(yōu)良輔料正在口服固體制劑的開(kāi)發(fā)中被越來(lái)越多地關(guān)注。從經(jīng)濟(jì)性與技術(shù)性評(píng)價(jià)兩方面分析了乳糖、纖維素衍生物、磷酸鹽、甘露醇等主流固體制劑填充與黏合劑的特點(diǎn)，以便為口服固體制劑中藥用輔料的篩選提供科學(xué)依據(jù)。

Pharmaceutical excipients are essential materials and important parts in pharmaceutical preparations. They play a key role in dosage forms and pharmaceutical industry production. Along with the rapid development of the production technology for pharmaceutical excipients, the pharmaceutical excipients with low hygroscopicity, inertness to raw material and human, good compressibility and good taste are becoming more and more popular in the oral solid preparations. The major excipients for oral solid preparations such as lactose, cellulose derivatives, phosphates and mannitol were evaluated both economically and technically in order to offer the scientific basis for the selection of pharmaceutical excipients in oral solid preparations.