噻嗪類利尿劑作為抗高血壓一線藥物，氯噻酮和氫氯噻嗪是這一類藥物中較常使用的利尿劑。近年來，氯噻酮、氫氯噻嗪引起了眾多研究者的關(guān)注，有證據(jù)顯示氯噻酮在治療高血壓的療效及減少心血管事件方面優(yōu)于氫氯噻嗪，但氯噻酮還遠(yuǎn)沒有氫氯噻嗪應(yīng)用廣泛。針對(duì)氯噻酮得不到廣泛應(yīng)用的原因，從臨床應(yīng)用、藥動(dòng)學(xué)、臨床藥效學(xué)等方面比較二者在減少心血管事件中的效果，并對(duì)氯噻酮、氫氯噻嗪各自復(fù)方制劑的研究進(jìn)展進(jìn)行了綜述。

Thiazide diuretics as first-line antihypertensive drugs, diuretic drugs of chlorthalidone and hydrochlorothiazide in this category are more commonly used. In recent years, chlorthalidone and hydrochlorothiazide attracted the attention of many researchers. Some evidences proved that the efficacy of chlorthalidone in the treatment of hypertension and reducing cardiovascular events was superior to hydrochlorothiazide, but the applications of chlorthalidone was far from hydrochlorothiazide. In this paper, aiming at the reasons of chlorthalidone not commonly used, the efficacy of chlorthalidone and hydrochlorothiazide on reducing of cardiovascular events was compared from clinical application, pharmacodynamics, clinical pharmacokinetics, and the research progress on the compounds of chlorthalidone and hydrochlorothiazide are also reviewed.