目的 考察球磨粉碎技術(shù)對刺五加中有效成分提取的影響。方法 采用超聲、冷浸法處理，以紫丁香苷、刺五加苷E、異嗪皮啶質(zhì)量分?jǐn)?shù)為指標(biāo)，采用高效液相色譜法比較了不同處理時間的刺五加球磨粉、粗粉、中粉和細(xì)粉。結(jié)果 隨著粉碎粒度的變細(xì)，刺五加中有效成分提取率明顯提高，球磨粉–超聲＞球磨粉–冷浸＞細(xì)粉–超聲＞中粉–超聲＞粗粉超聲＞中粉–冷浸＞細(xì)粉–冷浸＞粗粉–冷浸。其中球磨粉超聲60 min與常規(guī)粉碎的粗粉、中粉及細(xì)粉超聲60 min對比，紫丁香苷提高11.05%～56.56%、刺五加苷E提高26.04%～114.74%、異嗪皮啶提高24.10%～84.64%。結(jié)論 球磨粉碎技術(shù)能夠有效地提高刺五加中有效成分的提取率和提取速率，縮短樣品前處理時間，值得推廣應(yīng)用。

Objective To study the effect of ball pulverizing technology on extraction of the effective constituents in Acanthopanacis Senticosi Radix et Caulis. Methods Ultrasonic and cold leaching extract methods were used by using syringoside, eleutheroside E, and isofraxidin contents as indexes, and the ball pulverizing powder, coarse powder, middle powder, and fine powder treated in different times were compared by HPLC method. Results As the particle size was becoming finer, the leaching of the effective component in Acanthopanacis Senticosi Radix et Caulis was increased remarkably, namely ball pulverizing – ultrasonic > ball pulverizing-cold leaching > fine powder – ultrasonic > powder – ultrasonic > coarse powder – ultrasonic > powder-cold leaching > fine powder–cold leaching > coarse powder-cold leaching. Among them syringin increased 11.05% — 56.56%, eleutheroside E 26.04% — 114.74%, and isofraxidin 24.10% – 84.64%. Conclusion Ball pulverizing technology could effectively promote the extraction of the effective constituents in Acanthopanacis Senticosi Radix et Caulis, shorten the sample preparation time, which could be worthy of popularization and application.