目的 觀察異甘草酸鎂注射液治療重癥肝炎的臨床療效。方法 選取南京市第二醫(yī)院2008年12月—2013年3月149例重癥肝炎患者，隨機分為治療組（83例）和對照組（66例），治療組給予異甘草酸鎂注射液150 mg加入5%～10%葡萄糖注射液中靜脈滴注，1次/d；對照組給予復方甘草酸苷注射液160 mg加入5%～10%葡萄糖注射液中靜脈滴注，1次/d；治療期間，兩組還同時服用了保肝、抗病毒的藥物，兩組服用劑量和方法均相同，療程均為4周。治療結(jié)束后檢測兩組患者肝功能、凝血功能等指標變化。結(jié)果 與治療前相比，兩組患者治療后的肝功能指標均有明顯改善，治療組丙氨酸氨基轉(zhuǎn)移酶（ALT）、天門冬酸氨基轉(zhuǎn)移酶（AST）明顯低于對照組（P＜0.05）；兩組患者治療后的血清總膽紅素（TB）、直接膽紅素（DB）均有明顯降低（P＜0.05）；治療組患者治療后凝血酶原時間（PT）指標有明顯改善（P＜0.05）。結(jié)論 異甘草酸鎂注射液治療重癥肝炎有較好療效，可以改善患者的肝功能和凝血功能，值得臨床推廣應用。

Objective To observe the clinical effects of Magnesium Isoglycyrrhizinate Injection (MII) on serious hepatitis. Methods A tatal of 149 patients of serious hepatitis patients from The Second Hospital of Nanjing during December, 2008 to March, 2013 were randomly divided into treatment and control groups. The 83 serious hepatitis sufferers were treated with 150 mg MII added into 250 mL 5%—10% glucose injection liquid, other 66 sufferers as control group were treated with 160 mg Compound Glycyrrhizin Injection added into 250 mL 5%—10% glucose injection liquid, iv dripping once daily for 4 weeks. Drugs for protecting liver, antiviral were taken with the same dosage and the methods were the same for two groups. When the treatment was over, the practical effects were analyzed, such as liver function indexes and blood coagulation parameters. Results After treatment, the liver function index was significantly improved. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in treatment group were significantly lower than those in the control group (P < 0.05). There was a significant decrease of total bilirubin (TB) and direct bilirubin (DB) in two groups after treatment (P < 0.05). There were significant differences of PT index in treatment group (P < 0.05). Conclusion The blood coagulation and liver function index could be improved after treatment with MII in serious hepatitis sufferers, and there are few side reactions happened. It is worth for clinical use.