目的 觀察并評價(jià)硫酸嗎啡緩釋片聯(lián)合注射用益氣復(fù)脈（凍干）治療中晚期肝癌疼痛的療效。方法 將80例伴有疼痛的中晚期肝癌患者隨機(jī)分為治療組（40例）和對照組（40例），對照組中度疼痛者口服硫酸嗎啡緩釋片60 mg，12 h一次，重度疼痛者口服硫酸嗎啡緩釋片90 mg，12 h一次；治療組患者靜脈滴注0.9%生理鹽水250 mL＋注射用益氣復(fù)脈（凍干）3.9 g/次，1次/d，其他治療同對照組患者，兩組均治療14 d，并在治療前和治療后對患者疼痛和生活質(zhì)量進(jìn)行評估。結(jié)果 經(jīng)過治療，兩組疼痛程度均較前減輕（P＜0.05），生活質(zhì)量QOL評分和KPS評分高于治療前（P＜0.05）。其中治療組在疼痛程度VRS評分低于對照組（P＜0.05），生活質(zhì)量KPS和QOL評分治療組均高于對照組（P＜0.05）。不良反應(yīng)發(fā)生率除便秘外治療組明顯低于對照組（P＜0.01）。結(jié)論 硫酸嗎啡緩釋片聯(lián)合注射用益氣復(fù)脈（凍干）治療中晚期肝癌患者的疼痛療效明顯，能提高其生活質(zhì)量，同時(shí)能減輕嗎啡的不良反應(yīng)。

Objective To observe the clinical efficacy of Morphine Sulfate Sustained-release Tablets combined with Yiqi Fumai Injection (freeze-dried) in the treatment of advanced liver cancer pain. Methods Patients with advanced liver cancer pain (80 cases) were randomly divided into the treatment (40 cases) and control (40 cases) groups. In the control group, the patients with moderate and severe pain were po administered with Morphine Sulfate Sustained-release Tablets (60 and 90 mg, respectively), 12 h/time. The patients in the treatment group were iv administered with Yiqi Fumai Injection (freeze-dried), 3.9 g added into 250 mL physiological saline, once daily. The patients in the two groups were treated for 14 d. The pain and quality of life were evaluated before and after treatment. Results After treatment, the degree of pain in two groups were lower than that before treatment (P < 0.05), and scores of QOL and KPS were higher than those before treatment (P < 0.05). The pain score of VRS in the treatment group was lower than that in the control group (P < 0.05), and scores of KPS and QOL in treatment group were higher than those in the control group (P < 0.05). Incidence of adverse effect except constipation in the treatment group was significantly lower than that in the control group (P < 0.01). Conclusion Morphine Sulfate Sustained-release Tablets combined with Yiqi Fumai Injection (freeze-dried) has an accurate curative effect on the advanced liver cancer pain, which could improve the quality of life and reduce the adverse effect of morphine.