目的 觀察口炎清沖劑與氨來呫諾口腔貼片聯(lián)合治療復發(fā)性口瘡的臨床療效及其安全性。方法 選取樂山市人民醫(yī)院復發(fā)性口瘡患者90例，隨機分為對照組和治療組。對照組患者口服口炎清沖劑，20 g/次，2 次/d，連續(xù)服用2個月。治療組患者開始治療時，加用氨來呫諾口腔貼片，每日餐后和臨睡前口腔清潔后，將其在口腔潰瘍部位，輕壓10 s，連續(xù)用藥5 d，口炎清沖劑的用法、用量、治療時間同對照組。治療結束后詢問患者主觀感覺，癥狀改善情況，治療前、后口瘡疼痛評分，口瘡大小、數(shù)目等，同時判定兩組的臨床療效及不良反應。結果 治療組和對照組總有效率分別為97.78%、71.11%，兩組差異有統(tǒng)計學意義（P＜0.05）；治療后，兩組患者臨床癥狀均有所改善，所有患者較治療前口瘡疼痛評分降低，口瘡大小、數(shù)目均較治療前減少，差異有顯著性（P＜0.05），且治療組較對照組臨床癥狀改善更明顯（P＜0.05）；治療組患者不良反應發(fā)生率明顯低于對照組（P＜0.05）。結論 口炎清沖劑聯(lián)合氨來呫諾口腔貼片治療復發(fā)性口瘡療效明顯，不良反應發(fā)生率較低，可以在臨床上推廣應用。

Objective To observe the clinical efficacy and the safety of Kouyanqing Electuary combined with amlexanox oral patch in the treatment of recurrent aphtha. Methods The patients (90 cases) diagnosed with recurrent aphtha in the People’s Hospital of Leshan were randomly divided into treatment (45 cases) and control (45 cases) groups. The patients in the control group were po administered with Kouyanqing Granule, 20 g/once, twice daily, and they were treated for two months. The patients in the treatment group made ammonia to presence of oral patch on the ulcer site, and then gently pressed 10 s after meals and before bed after patients’ oral cavity cleaned for 5 d, and other treatment was the same as the control group. After the treatment, the subject feeling, improvement of symptoms, pain scores before and after treatment, ulcer size and number were observed. At the same time, the adverse drug reactions were observed. Results The efficiency for the patients in both the treatment and control groups was 97.78% and 71.11% with significant difference (P < 0.05). After the treatment, the clinical symptoms of the two groups were improved, and pain scores, ulcer size and number were decreased. Clinical symptoms in the treatment group were improved more obviously than those in the control group (P < 0.05), and the incidence of adverse drug reactions was lower than those of the control group. Conclusion Kouyanqing Electuary combined with amlexanox oral patch has a accurate curative effect on the recurrent ulcers with low incidence of adverse drug reactions, which could be used in clinic.