目的 探索熱毒寧注射液與阿昔洛韋配伍的穩(wěn)定性。方法 在室溫25 ℃觀察兩種藥物混合液在60 min內(nèi)的外觀、pH值、光譜圖變化。結(jié)果 兩種藥物較高濃度混合液會(huì)立即出現(xiàn)渾濁和顏色改變，較低濃度混合液的外觀清澈透明、微黃；低濃度混合液60 min內(nèi)的pH值穩(wěn)定；各時(shí)間點(diǎn)的吸光度值顯著下降，質(zhì)量分?jǐn)?shù)明顯減少。結(jié)論 熱毒寧注射液與阿昔洛韋無(wú)論濃度高低均存在配伍禁忌，建議避免混合應(yīng)用。

Objective To investigate the compatible stability of Reduning Injection with acyclovir. Methods Changes of appearance, pH value and absorption spectrum in the mixture of Reduning Injection with acyclovir were observed at room temperature (25 ℃) for 60 min. Results The mixture became turbid and the color changed immediately when the concentrations of Reduning Injection with acyclovir was higher. While at the lower concentration, the mixture was clear, its color became a little yellow, and the pH value was stable during 60 min;. The absorbance value dropped in different time points, which meant the relative content of each component decreased. Conclusion Reduning Injection should be avoided to use with acyclovir for the imcompatibility between them no matter the concentration is high or not.