目的 測(cè)定阿戈美拉汀不純品中雜質(zhì)相對(duì)校正因子。方法 利用多個(gè)未知量聯(lián)立方程法計(jì)算阿戈美拉汀雜質(zhì)的相對(duì)校正因子，并對(duì)本法進(jìn)行對(duì)比驗(yàn)證。結(jié)果 計(jì)算出二氫阿戈美拉汀粗品和四氫阿戈美拉汀粗品的相對(duì)校正因子，即f2=0.228，f4=0.065，并利用相對(duì)校正因子計(jì)算供試品中各組分質(zhì)量分?jǐn)?shù)，確定雜質(zhì)的定量方法。結(jié)論 該方法可用于檢測(cè)含多個(gè)未知校正因子組分的樣品，省去阿戈美拉汀樣品提純的繁瑣，為雜質(zhì)定量方法的確定提供參考。

Objective To determine the relative correction factor of impurity in crude agomelatine. Methods The combination of several unknown parameters was used to establish simultaneous equations for calculating relative correction factor of impurity in agomelatine, and this method was verified by contrast test. Results The relative correction factors of crude dihydroagomelatine and crude tetrahydroagomelatine were obtained by this method with f2 being 0.228 and f4 being 0.065. Based on relative correction factors , content of each component in samples was calculated, and the quantitative methods of impurities were established. Conclusion This method could be used for determination of samples with multi relative correction factors without purifying and provide guidance for the quantitative method of impurity.