內(nèi)質(zhì)網(wǎng)應(yīng)激是一種細(xì)胞自我保護(hù)性機(jī)制的信號反應(yīng)通路系統(tǒng)，參與許多疾病的生理病理過程。內(nèi)質(zhì)網(wǎng)應(yīng)激參與多種肝臟損傷的發(fā)生與發(fā)展，包括免疫性肝損傷、病毒性肝損傷、中毒性肝損傷、脂肪性肝損傷等。以內(nèi)質(zhì)網(wǎng)應(yīng)激為切入點(diǎn)，深入探討內(nèi)質(zhì)網(wǎng)應(yīng)激的分子機(jī)制、作用功能，以及內(nèi)質(zhì)網(wǎng)應(yīng)激與各種肝損傷之間的關(guān)系。結(jié)合臨床藥物的作用機(jī)制，內(nèi)質(zhì)網(wǎng)應(yīng)激可能成為治療肝臟損傷相關(guān)疾病的新靶點(diǎn)。

Endoplasmic reticulum stress (ERS) is a self-protecting regulation system, which is involved in various physiologial and pathological conditions. It is reported that ERS contributes to the occurrence and development of liver injury, including immunological liver injury, viral hepatitis, hepatic adipose infiltration, and hepatotoxicity, and so on. This review is about the mechanism of ERS on hepatocytes in the pathogenesis of a variety of liver injuries. Combining with the clinical studies, ERS might be a novel therapeutic target in liver injury-related disease.

“十一五”科技重大專項(xiàng)（2009ZX09302-002）；中醫(yī)藥行業(yè)科研專項(xiàng)（200707008）；中央高?；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金（ZJ10115）