摘 要：目的 研究精制原人參二醇皂苷（PDS）對(duì)亞硝酸鈉、乙醇和東莨菪堿所致小鼠記憶障礙的改善作用。方法 連續(xù)給精制PDS組、陽(yáng)性對(duì)照藥石杉?jí)A甲組小鼠ig相應(yīng)藥物2周，正常和模型對(duì)照組小鼠ig等量生理鹽水，末次給藥1 h后，除空白組sc等量生理鹽水外，其余各組均立即sc亞硝酸鈉、或乙醇、或東莨菪堿，用被動(dòng)回避實(shí)驗(yàn)觀察PDS對(duì)小鼠學(xué)習(xí)記憶功能的影響，并比較精制PDS與粗品PDS、人參皂苷Rb1單體的改善學(xué)習(xí)記憶的作用。結(jié)果 精制PDS各劑量均有良好的改善小鼠記憶障礙的作用；與精制PDS相比，同樣劑量的粗品PDS和人參皂苷Rb1單體則均未顯示改善記憶的作用。結(jié)論 精制PDS是極有前途的益智藥物或保健產(chǎn)品的原料。

Abstract：Objective To investigate the effects of notoginseng saponins containing high-concentration protopanaxadiol（PDS）on dysmnesia of mice induced by sodium nitrite，ethanol and scopolamine．Methods Mice in experimental groups were intragastrically administrated tested drugs for two weeks continuously，and mice in normal group and model control group were intragastrically administered the same amount of physiological saline．The functions of improving learning and memory of PDS were evaluated by using passive shock avoidance paradigm，and were compared with those of crude PDS and single saponins Rb1．Results The results showed that different doses of refined PDS improved significantly the memory disorder of mice．But the same doses of single ginsenoside Rb1 and crude PDS had no effects on scopolamine-induced dysmnesia．Conclusion High concentration of PDS may be quite promising materials of nootropics drugs and health products．