目的 觀察養(yǎng)血生發(fā)膠囊對C57BL/6小鼠毛發(fā)生長的影響，并探討其可能的作用機(jī)制。方法 采用C57BL/6小鼠脫發(fā)實驗?zāi)Ｐ?，觀察毛發(fā)生長情況，并于脫毛后第9、19天，做脫毛區(qū)皮膚毛囊數(shù)、毛細(xì)血管及毛囊血管內(nèi)皮生長因子(VEGF)檢測。結(jié)果 養(yǎng)血生發(fā)膠囊明顯縮短小鼠皮膚變黑時間；明顯增加皮膚毛囊數(shù)、毛囊毛細(xì)血管數(shù)及毛囊組織中VEGF表達(dá)積分吸光度(A)值。結(jié)論 養(yǎng)血生發(fā)膠囊通過增加毛囊組織中VEGF表達(dá)、毛囊血管數(shù)及毛囊數(shù)，促進(jìn)毛發(fā)生長。

Objective To investigate the effect of Yangxue Shengfa Capsules on hair growth of mice, and to detect the possible mechanism of hair growth promotion by using vascular endothelial growth factor (VEGF). Methods C57BL/6 mice were chosen as experimental animals. Hair re-growth was observed, and the number of hair follicles, capillary and VEGF in hairless zone were determined on 9 and 19 day after the depilation. Results Yangxue Shengf Capsules shortened significantly the time of skin darkening. Compared with model group, there was significant increase in hair follicle number and skin blood vessels as well as the integrated optical density (A of VEGF in Yangxue Shengfa group. Conclusion Yangxue Shengfa Capsules can promote hair growth by increasing A of VEGF, hair follicle number and skin blood vessels.