自從紫杉醇廣泛應(yīng)用于臨床治療以來，與微管作用的抗腫瘤天然產(chǎn)物的發(fā)現(xiàn)、化學(xué)修飾和機(jī)制研究已經(jīng)成為學(xué)術(shù)和臨床研究的熱點(diǎn)。介紹了與微管作用的抗腫瘤天然產(chǎn)物的研究情況，包括紫杉醇、埃博霉素、discodermolid、考布他汀、軟海綿素、海兔毒素、那可丁等，簡(jiǎn)要探討了目前存在的問題和未來的發(fā)展方向。

After taxol was widely used in clinical treatments, the discovery, chemical modification and mechanism study of anticancer natural products with tublin-interactive properties have become focal point of research both in academic and clinical field. This review provides brief information and recent development of anticancer natural products with tublin-interactive properties such as Paclitaxel, epothilones, discodermolid, combretastatin, halichondrin, dolastatin, noscapine. The disadvantage and future development of anticancer agents are also discussed in this article.