[關(guān)鍵詞]
[摘要]
目的 觀察芹菜根提取物對(duì)四氯化碳(CCI4)所致大鼠急性肝損傷的作用.方法 50只Wistar大鼠隨機(jī)分為5組:陰性對(duì)照組、模型對(duì)照組、陽性對(duì)照組、芹菜根高、低劑量給藥組,高、低劑量組分別灌胃3、1.5 g/kg芹菜根提取物,陽性對(duì)照組灌胃200mg/kg聯(lián)苯雙酯滴丸,陰性對(duì)照組及模型對(duì)照組以等體積生理鹽水灌胃,共7 d.第7天,模型對(duì)照組、陽性對(duì)照組和各給藥組ip CCl4溶液1 mL/kg,正常組注射等體積生理鹽水.測(cè)定各組大鼠血清天冬氨酸轉(zhuǎn)氨酶(AST)、丙氨酸轉(zhuǎn)氨酶(ALT),肝組織中超氧化物歧化酶(SOD)活性和丙二醛(MDA)的量,并觀察肝組織病理改變.結(jié)果 芹菜根提取物能顯著降低CCI4所致大鼠血清AST、ALT量的升高及肝組織中MDA的量,增強(qiáng)肝組織中SOD活性.結(jié)論 芹菜根提取物對(duì)CCI4所致的大鼠急性肝損傷具有一定的保護(hù)作用.
[Key word]
[Abstract]
Objective To observe the effect of celery root on acute liver injury induced by CCl4in rats.Methods Fifty rats were randomly divided into normal control group,model control group,position control group,high-dosage and low-dosage celery root extract group.The rats in all groups were administered for 7 d.The high-dosage and low-dosage celery root extract groups were pretreated intragastrically with 3,1.5 g/kg celery root extract,and position control group were pretreated intragastrically bifendate pills 200 m...
[中圖分類號(hào)]
R285.5
[基金項(xiàng)目]
新疆高等學(xué)?？蒲许?xiàng)目 ?
