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Archive > Volume 2 Issue 4 > 2010,2(4):245-247. DOI:10.3969/j.issn.1674-6384.2010.04.001 Prev Next

Letter

A New Compound with Anti-oxidative Activity from Seeds of Jatropha curcas

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    摘要:
    The papers in the journal of Chinese Traditional and Herbal Drugs in Vol. 40, 2009 are briefly reviewed in the categories of chemical constituents, preparations and technologies, analysis and quality control, pharmacological and clinical studies, reviews, and finally healthy principles. Some comments, especially for hot topics have been personally provided.

    Abstract:
    Objective To search for chemical constituents with anti-oxidative activities from seeds of Jatropha curcas. Methods DPPH radical scavenging assay was used to screen fractions or constituents with anti-oxidative activities. Active fractions were separated by varied chromatography and then identified on the basis of physiochemical properties and spectroscopic methods. Results The n-butanol layer of ethanol extract from the seeds of J. curcas showed stronger activity than other fractions and was studied further. A new compound was isolated from this active layer, and its structure was identified as jatrophasin A (3,4,4′,5′-tetrahydroxyl-3′-methoxyl-bisepoxylignan) (1). It showed stronger anti-oxidative activity compared with resveratrol. Conclusion Compound 1 is a new compound which has never been reported with strong anti-oxidative activity.

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