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Archive > Volume 17 Issue 3 > 2025,17(3):473-483. DOI:https://doi.org/10.1016/j.chmed.2024.04.003 Prev Next

冰片作為藥物制劑增強(qiáng)劑的作用

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Role of borneol as enhancer in drug formulation: A review

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    摘要:
    冰片作為一種傳統(tǒng)中藥，自古以來就與其他中藥配合使用，表現(xiàn)出卓越的抗炎和鎮(zhèn)痛活性。此外，冰片被認(rèn)為可以提高藥物的血液濃度和生物利用度。因此，自古以來就與各種中藥配方相配。人體的生理障礙會(huì)導(dǎo)致藥物效率的顯著限制，被限制進(jìn)入血液和大腦。冰片已被證明可以增強(qiáng)生物屏障的滲透性，例如血腦屏障、透皮屏障、角膜屏障和腸道屏障等。此外，越來越多研究對冰片跨屏障運(yùn)輸?shù)乃幬镙斔拖到y(tǒng)設(shè)計(jì)感興趣。納米藥物遞送系統(tǒng)具有增加的表面積和改善的活性位點(diǎn)，已被應(yīng)用于提高水不溶性藥物的生物活性。與傳統(tǒng)的中藥制劑給藥方法相比，納米制劑的使用已被證實(shí)可以通過減少作用時(shí)間來增強(qiáng)藥物功效。由于冰片具有增強(qiáng)跨屏障滲透和藥效的能力，因此已將其納入中藥藥效成分制劑的藥物輸送系統(tǒng)中，以實(shí)現(xiàn)對腫瘤部位的精確和長時(shí)間靶向。然而，由冰片組成的藥物遞送系統(tǒng)的設(shè)計(jì)和制備仍然面臨著巨大的挑戰(zhàn)。目前的研究未能闡明由冰片組成的納米藥物遞送系統(tǒng)和與冰片結(jié)合的傳統(tǒng)藥物制劑給藥之間作用機(jī)制的差異。在劑量和醫(yī)學(xué)適應(yīng)癥方面，暫時(shí)沒有研究可證實(shí)冰片在同種藥物遞送系統(tǒng)中與傳統(tǒng)中藥制劑給藥方法的生物屏障滲透增強(qiáng)。本研究概述了冰片的性質(zhì)、配方和藥理作用的研究現(xiàn)狀，對冰片與單一化合物和經(jīng)典中藥配方制劑針對各種醫(yī)學(xué)適應(yīng)癥的交叉比較。本研究旨在對基于冰片的跨屏障遞送藥物制劑的設(shè)計(jì)、以及用于含冰片的傳統(tǒng)中藥配方制劑的納米藥物系統(tǒng)開發(fā)的潛能提供思路，以期望達(dá)到增強(qiáng)生物利用度的目的。

    Abstract:
    As a traditional Chinese medicine (TCM), borneol has shown superior ability for anti-inflammatory and analgesic activities when coupled with other active ingredients from ancient times. Furthermore, borneol is believed to improve blood concentration and bioavailability of drugs. Thus, it has been paired with various TCM formulas since ancient time. The physiological barriers in human can cause significant limitations in drug efficiency as the drug is primarily restricted from entering into blood and brain. Borneol has been proven to enhance the permeability of biological barriers such as the blood–brain, transdermal, corneal, and intestinal barriers. Moreover, growing interest has been shown in the drug delivery system design for trans-barrier transport involving borneol. Nano drug delivery system with increased surface area and improved active sites, has been applied to increase the bioactivity of water insoluble drugs. Nano-drug delivery system has been used to enhance drug efficacy by reducing the time of action as compared to conventional administration approach of TCM formulas. Given its ability to enhance crossbarrier permeation and drug efficacy, borneol has been integrated into TCM formulas of drug delivery system for precise and prolonged targeting at tumor sites. However, the design and preparation of a drug delivery system consisting of borneol still face great challenges. Current research fails to unravel the difference in mechanism of action between nano-drug delivery systems comprised of borneol and conventional drug systems coupled with borneol. Enhanced penetration of borneol in drug delivery system is rarely verified compared to conventional administration with identical drug formulation consisting of borneol regarding dosage and medical indications. This study outlines the current state of research on the properties, formulation and pharmacological effects of borneol, allowing cross-comparison of borneol coupled with single compound and classical TCM formulas for various medical indications. This study aims to provide insights into the design of borneol-based enhanced cross-barrier delivery drug formulation, and the potential development of nano-drug system for TCM formulas with borneol for enhanced bioavailability.

    關(guān)鍵詞:
    冰片;納米技術(shù);促進(jìn)滲透作用;敏化劑;跨膜運(yùn)輸

    Keywords:


    Project Supported:
    This work was supported by 2021 Traditional Chinese Medicine (Medicine of South China) Industry Talents Project-Innovation Team of South China Medicine Resources, Yunfu and the State Administration of Traditional Chinese Medicine high-level key discipline construction project (No. zyyzdxk-2023186).

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