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Archive > Volume 16 Issue 4 > 2024,16(4):561-571. DOI:https://doi.org/10.1016/j.chmed.2024.07.005 Prev Next

蘆薈及其配伍方劑治療便秘的研究進(jìn)展

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Treatment of constipation with Aloe and its compatibility prescriptions

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    摘要:
    便秘是臨床常見且流行的消化系統(tǒng)疾病，嚴(yán)重影響人類身心健康。目前，化學(xué)藥物具有較好的近期治療效果，但由于其不良反應(yīng)、停藥后易復(fù)發(fā)、長(zhǎng)期使用有依賴性，遠(yuǎn)期療效不理想。便秘病機(jī)為癥多責(zé)之于臟腑氣血陰陽(yáng)不足，證屬本虛標(biāo)實(shí)。蘆薈是一味中國(guó)傳統(tǒng)中藥，具有寒性和苦味，也是治療便秘最常用的草藥之一。本文從蘆薈及其單體成分出發(fā)，結(jié)合蘆薈現(xiàn)有的配伍關(guān)系研究以及以蘆薈為代表的中成藥，從基礎(chǔ)實(shí)驗(yàn)到臨床觀察，全面系統(tǒng)的介紹了蘆薈及其配伍方劑治療便秘的研究進(jìn)展，為臨床合理應(yīng)用蘆薈及其方劑治療便秘提供理論依據(jù)和用藥指導(dǎo)，同時(shí)也為今后研究蘆薈治療便秘的作用機(jī)制提供方向

    Abstract:
    Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term efficacy is unsatisfactory. The pathogenesis of constipation is mainly attributed to dysfunction of zang-fu organs and imbalance of qi-blood and yin-yang, with the syndrome being asthenia in origin and asthenia in superficiality. Aloe is a traditional Chinese medicine with cold properties and a bitter taste, and one of the most commonly used herbs for constipation. Based on Aloe and its monomer components, combined with the existing compatibility studies of Aloe and several Chinese patent drugs represented by Aloe, this paper comprehensively and systematically introduced the research progress of Aloe and its compatibility prescriptions in the treatment of constipation from basic experiments to clinical observations, providing theoretical basis and medication guidance for the clinical rational application of Aloe and its prescriptions in the treatment of constipation. At the same time, it also provides the direction for future research on the mechanism of Aloe in the treatment of constipation.

    關(guān)鍵詞:
    蘆薈;蘆薈大黃素;大黃酸;首薈通便膠囊;胃腸激素;臨床研究

    Keywords:


    Project Supported:
    This work was supported by National Key Research and Development Program (No. 2022YFC3502100, 2022YFC3502102-05), Joint Fund of Natural Fund of Shandong Province (No. ZR2021LZY036), Lunan Hope Pharmaceutical Co., Ltd. (No. 1520019013).

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