Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms

doi:https://doi.org/10.1016/j.chmed.2024.09.006

Archive > Volume 16 Issue 4 > 2024,16(4):489-504. DOI:https://doi.org/10.1016/j.chmed.2024.09.006 Prev Next

人參皂苷Rb1與心腦血管疾?。褐委煗摿捌浞肿訖C(jī)制

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Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms

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摘要:

：心腦血管疾病是由心臟缺陷和血管疾病引起的一種循環(huán)系統(tǒng)疾病，是影響全球公共衛(wèi)生的主要非傳染性疾病之一。隨著經(jīng)濟(jì)水平的提高和人們生活方式的改變，心腦血管疾病的患病率不斷上升。人參(Panax ginseng C. A. Mey.)因其滋補(bǔ)作用而被廣泛用于傳統(tǒng)疾病中。人參皂苷Rb1 (G-Rb1)是從人參中提取的最豐富的且具有多種藥理作用的活性成分，已被證明通過(guò)抗氧化、抗炎、調(diào)節(jié)血管舒張、減少血小板粘附、影響鈣離子通道、改善脂質(zhì)分布、參與葡萄糖代謝等多種機(jī)制對(duì)心血管系統(tǒng)具有潛在的益處。本文針對(duì)G-Rb1對(duì)動(dòng)脈粥樣硬化、高血壓、冠心病、缺血性腦卒中、眼周微血管視網(wǎng)膜病變等心腦血管疾病的保護(hù)作用及其可能機(jī)制進(jìn)行綜述。最后，作者回顧并報(bào)道了G-Rb1改善心腦血管疾病的體內(nèi)和體外實(shí)驗(yàn)結(jié)果，并強(qiáng)調(diào)了其有效性、安全性和局限性。

Abstract:

Cardiovascular and cerebrovascular diseases (CCVDs), which are circulatory system diseases caused by heart defects and vascular diseases, are the major noncommunicable diseases affecting global public health. With the improvement of economic level and the change of human lifestyle, the prevalence of CCVDs continues to increase. Ginseng (Panax ginseng C. A. Mey.) was widely used in traditional diseases due to its supposed tonic properties. Ginsenoside Rb1 (G-Rb1) is the most abundant active ingredient with multiple pharmacological effects extracted from ginseng, which has been shown to have potential benefits on the cardiovascular system through a variety of mechanisms, including anti-oxidation, antiinflammatory, regulation of vasodilation, reduction of platelet adhesion, influence of calcium ion channels, improvement of lipid distribution, involving in glucose metabolism and controlling blood sugar. This review reviewed the protective effects of G-Rb1 on CCVDs and its potential mechanisms, such as atherosclerosis (AS), hypertension, coronary heart disease (CHD), ischemic stroke (IS) and periocular microvascular retinopathy. Finally, we reviewed and reported the results of in vivo and in vitro experiments using G-Rb1 to improve CCVDs, highlighted its efficacy, safety, and limitations.

關(guān)鍵詞:

人參皂苷Rb1;動(dòng)脈粥樣硬化;心腦血管疾病;冠心病;高血壓;缺血性腦卒中;眼周微血管視網(wǎng)膜病變

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This work was supported by the grants of National Natural Science Foundation of China (No. 82104465).

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