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Archive > Volume 16 Issue 2 > 2024,16(2):239-247. DOI:https://doi.org/10.1016/j.chmed.2023.05.006 Prev Next

首薈通便膠囊治療便秘的療效及機(jī)制研究進(jìn)展

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Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development

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    摘要:
    便秘是臨床上常見(jiàn)的消化系統(tǒng)疾病，隨著飲食結(jié)構(gòu)的改變和生活壓力的增大，其患病率逐年升高。中醫(yī)認(rèn)為，便秘病位在大腸，與肺脾肝腎等臟腑的功能失調(diào)有關(guān)，其病機(jī)為大腸通降不利、傳導(dǎo)失司。首薈通便膠囊正是依據(jù)此理論而制得的中成藥，由何首烏、蘆薈、決明子、枸杞子、阿膠、人參、白術(shù)、枳實(shí)八味中藥構(gòu)成，瀉濁通便，養(yǎng)陰益氣，治療便秘療效顯著，且未見(jiàn)明顯不良反應(yīng)。本文對(duì)首薈通便膠囊治療便秘的最新進(jìn)展進(jìn)行綜述，主要包括首薈通便膠囊治療功能性便秘、惡性腫瘤化療相關(guān)性便秘、結(jié)腸炎便秘、2型糖尿病便秘、慢性心力衰竭便秘的臨床和基礎(chǔ)研究。本文將為臨床應(yīng)用首薈通便膠囊治療便秘提供理論依據(jù)和指導(dǎo)，同時(shí)為今后探索首薈通便膠囊治療其他類型便秘提供方向。

    Abstract:
    Constipation is common in the diseases of the digestive system in clinics. With the change in diet structure and the increase in life pressure, the prevalence rate increases year by year. In traditional Chinese medicine (TCM), the location of the disease of constipation is in the large intestine, which is related to the dysfunction of lung, spleen, liver, kidney and other viscera. Its pathogenesis is conductive dysfunction of large intestine. Based on the theory, Shouhui Tongbian Capsule (SHTB) is composed of eight traditional Chinese medicines, including Polygoni multiflori Radix (Heshouwu in Chinese), Aloe (Luhui in Chinese), Cassiae Semen (Juemingzi in Chinese), Ginseng Radix et Rhizoma (Renshen in Chinese), Lycii Fructus (Gouqizi in Chinese), Asini Corii Colla (Ejiao in Chinese), Aurantii Fructus Immaturus (Zhishi in Chinese), and Atractylodis Macrocephalae Rhizoma (Baizhu in Chinese), which could help to release excessive turbid, and nourishing yin and supplementing qi in the treatment. This study has been carried out to review the latest advances of SHTB in the treatment of constipation. The results showed that significant effect of SHTB was found in the treatment of constipation, such as functional constipation, and constipation associated with tumor chemotherapy, colitis, type 2 diabetes and chronic cardiac failure. Besides, obvious adverse reactions were not observed. SHTB could effectively treat five types of constipation, provide direction for the future exploration of SHTB in the treatment of other types of constipation.

    關(guān)鍵詞:
    便秘;胃腸激素;cajal間質(zhì)細(xì)胞;腸液分泌;腸道蠕動(dòng);首薈通便膠囊

    Keywords:


    Project Supported:
    The work was supported by National Key R & D Program of China (No. 2022YFC3502100), Cutting Edge Development Fund of Advanced Medical Research Institute, Lunan Hope Pharmaceutical Co., Ltd. (No. 1520019013), the Scientific and Technological Innovation Program for Clinical Medicine of Jinan (No. 202019132) and Cultivation Fund Program of the Second Hospital of Shandong University (No. 2022YP14).

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