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Archive > Volume 16 Issue 1 > 2024,16(1):70-81. DOI:https://doi.org/10.1016/j.chmed.2023.06.003 Prev Next

裂環(huán)prezizaane型倍半萜的化學成分及藥理活性研究進展

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Chemical composition and pharmacological activity of seco-prezizaane-type sesquiterpenes

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    摘要:
    裂環(huán)prezizaane型倍半萜(SPS)是一類從八角屬植物中分離得到的具有高度氧化的五環(huán)籠狀結構和七個連續(xù)手性中心的特殊倍半萜，具有多種生物活性，包括神經(jīng)毒性和神經(jīng)營養(yǎng)作用等。本文綜述了SPS的化學成分和藥理作用，并對其潛在的研究趨勢和方向進行了討論。

    Abstract:
    The seco-prezizaane-type sesquiterpenes (SPS), as a special class of sesquiterpenes with a highly oxidative five-ring cage structure and seven consecutive chiral centers, are isolated from the genus Illicium, which have a variety of biological activities, including neurotoxicity and neurotrophic effects, etc. This review summarizes the chemical constituents and pharmacological effects of SPS, and discusses the potential trend and scope of future research.

    關鍵詞:
    莽草毒素;化學成分;八角屬;大八角素;藥理作用;裂環(huán)prezizaane型倍半萜

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    Project Supported:
    This work was financially supported by Yunnan Provincial Science and Technology Department-Applied Basic Research Joint Special Funds of Chinese Medicine (No. 202101AZ070001-004); Major Science and Technology Special Project from Yunnan Provincial Science and Technology Department (No. 202202AA100009, 202302AA310006); Universities Engineering Research Center of Yunnan Province (No. 2020YGG01), and Open and Shared Public Science and Technology Service Platform of Traditional Chinese Medicine Science and Technology Resources in Yunnan.

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