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Archive > Volume 16 Issue 1 > 2024,16(1):56-69. DOI:https://doi.org/10.1016/j.chmed.2023.09.006 Prev Next

骨折早期愈合過程中缺氧誘導(dǎo)因子-1α相關(guān)機(jī)制及中醫(yī)藥的干預(yù)作用

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Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

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    摘要:
    骨折作為一種常見的臨床疾病，常伴有疼痛、腫脹、出血等癥狀，致殘率高，甚至威脅生命，嚴(yán)重影響患者的身心健康和生活質(zhì)量。醫(yī)生采取了包括中藥在內(nèi)的多種治療骨折愈合的策略。骨折愈合早期，局部骨折常處于缺氧狀態(tài)，并伴有缺氧誘導(dǎo)因子-1α（HIF-1α）的表達(dá)，這有利于傷口愈合。通過文獻(xiàn)挖掘，我們認(rèn)為缺氧、HIF-1α和下游因素影響骨折愈合的機(jī)制，并主導(dǎo)了這一過程。因此，我們系統(tǒng)綜述了骨折愈合過程中的局部特征和相關(guān)信號通路，并總結(jié)了藥對這些機(jī)制的干預(yù)，以啟發(fā)骨折愈合的新策略，并基于HIF分子機(jī)制闡述了中藥治療骨折的可能原理。

    Abstract:
    As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients’ physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.

    關(guān)鍵詞:
    骨折愈合;缺氧;缺氧誘導(dǎo)因子-1α;中醫(yī)藥;分子機(jī)制

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    Project Supported:
    This work is financially supported by National Natural Science Foundation of China (No. 82060877, 82104527), the Science and Technology Planning Project of Tibet Autonomous Region (No. XZ202101ZD 0022G), the Fundamental Research Funds for the Central Universities (No. lzujbky-2022-ct03).

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