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Archive > Volume 16 Issue 1 > 2024,16(1):42-55. DOI:https://doi.org/10.1016/j.chmed.2023.08.001 Prev Next

基于8種平-苦中藥探索該類(lèi)藥物調(diào)節(jié)腸道菌群的潛在作用與機(jī)制

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Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

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    摘要:
    性平味苦(MB)中藥是一類(lèi)被廣泛應(yīng)用于臨床實(shí)踐的中藥，可用于慢性疾病的長(zhǎng)期治療。然而，MB中藥作為一類(lèi)重要的中藥，其藥理作用機(jī)制尚未得到系統(tǒng)的綜述。腸道菌群可以介導(dǎo)中藥的治療活性，并有助于闡明中醫(yī)理論原則的科學(xué)內(nèi)涵。在本系統(tǒng)綜述中，我們發(fā)現(xiàn)MB中藥普遍參與代謝綜合征(10/29)、腸道炎癥(5/29)、神經(jīng)系統(tǒng)疾病(4/29)和心血管系統(tǒng)疾病(3/29)的治療，具有促進(jìn)有益細(xì)菌Bacteroides, Akkermansia, Lactobacillus, Bifidobacterium和Roseburia增殖，并抑制有害菌Helicobacter, Enterococcus, Desulfovibrio和Escherichia-Shigella生長(zhǎng)的作用。這些菌群的改變可以促進(jìn)活性物質(zhì)，如短鏈脂肪酸(SCFAs)、膽汁酸(BAs)、5-羥色胺(5-HT)、吲哚和γ-氨基丁酸(GABA)的產(chǎn)生，同時(shí)抑制有害代謝物，如促炎因子氧化三甲胺(TAMO)和脂多糖(LPS)的釋放，進(jìn)一步通過(guò)不同的信號(hào)通路發(fā)揮治療作用。總而言之，本綜述通過(guò)建立中藥-腸道菌群-代謝物-信號(hào)通路-疾病軸，全面總結(jié)MB中藥與腸道菌群的關(guān)系，以期能為中醫(yī)藥性理論的現(xiàn)代化研究和臨床應(yīng)用提供新的思路。

    Abstract:
    The mild-natured and bitter-flavored traditional Chinese medicines (MB-TCMs) are an important class of TCMs that have been widely used in clinical practice and recognized as safe long-term treatments for chronic diseases. However, as an important class of TCMs, the panorama of pharmacological effects and the mechanisms of MB-TCMs have not been systemically reviewed. Compelling studies have shown that gut microbiota can mediate the therapeutic activity of TCMs and help to elucidate the core principles of TCM medicinal theory. In this systematic review, we found that MB-TCMs commonly participated in the modulation of metabolic syndrome, intestinal inflammation, nervous system disease and cardiovascular system disease in association with promoting the growth of beneficial bacteria Bacteroides, Akkermansia, Lactobacillus, Bifidobacterium, Roseburia as well as inhibiting the proliferation of harmful bacteria Helicobacter, Enterococcus, Desulfovibrio and Escherichia-Shigella. These alterations, correspondingly, enhance the generation of protective metabolites, mainly including short-chain fatty acids (SCFAs), bile acid (BAs), 5-hydroxytryptamine (5-HT), indole and gamma-aminobutyric acid (GABA), and inhibit the generation of harmful metabolites, such as proinflammatory factors trimethylamine oxide (TAMO) and lipopolysaccharide (LPS), to further exert multiplicative effects for the maintenance of human health through several different signaling pathways. Altogether, this present review has attempted to comprehensively summarize the relationship between MB-TCMs and gut microbiota by establishing the TCMs-gut microbiota-metabolite-signaling pathway-diseases axis, which may provide new insight into the study of TCM medicinal theories and their clinical applications.

    關(guān)鍵詞:
    膽汁酸;γ-氨基丁酸;5 -羥色胺;性平味苦中藥;藥性理論;短鏈脂肪酸;中藥;氧化三甲胺

    Keywords:


    Project Supported:
    The authors acknowledge the financial supports of the National Natural Science Foundation of China (No. 81973217, 82174340).

    Clc Number:

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