0.05). Conclusion The traditional and machinery decoctions of DCQD are bioequivalent."/>

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Archive > Volume 7 Issue 4 > 2015,7(4) Prev Next

Comparison on Traditional and Machinery Decoctions for Da-cheng-qi Decoction Based on Chemical Ingredients, Pharmacological Functions, and Clinical Trials

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    摘要:


    Abstract:
    Objective Patients and doctors often have questions about the equivalence of traditional and machinery decoctions. In this article, using Da-cheng-qi Decoction (DCQD) as a model of formula, traditional decoction (TD), machinery decoction under high pressure (MDHP), and machinery decoction under normal pressure (MDNP) were compared. Methods For chemical structures, HPLC fingerprints were established and evaluated using AHP combined with CRITIC weighing method; For animals’ effects, the experiments of small intestinal propulsion were conducted; For clinical effects, a randomized clinical trial (RCT) was designed and performed. Results Although there were some differences between TD and MDNP for chemical ingredients, there was no significant difference for animal experiments and clinical trials (P > 0.05). Conclusion The traditional and machinery decoctions of DCQD are bioequivalent.

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    Project Supported:
    Longhua Medical Project (LYTD-14), National special research foundation of TCM (No. 201007010).

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