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Archive > Volume 6 Issue 2 > 2014,6(2):93-102. DOI:10.1016/S1674-6384(14)60014-9 Prev Next

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Traditional Chinese Medicine for Diminished Ovarian Reserve: A Systematic Review and Meta-analysis

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    Abstract:
    Objective To assess the effectiveness and safety of traditional Chinese medicine (TCM) for women with diminished ovarian reserve (DOR). Methods A literature search was conducted in eight electronic databases for randomized controlled trials. Results Seventeen randomized controlled trials involving 1174 patients were included. Meta-analysis indicated that TCM was superior to Western medicine (WM) in reducing basal serum FSH level [MD = -1.70, 95% CI (-2.63, -0.77); P = 0.0004] and FSH/LH (MD = -0.43, 95% CI [-0.56, -0.30]; P = 0.0001), and the effect was more obvious two months after the last treatment (MD = -4.60, 95% CI [-6.26, -2.90], P < 0.000 01 and MD = -0.56, 95% CI [-0.85, -0.28], P = 0.0001), and increasing antral follicle count (AFC) (MD = 0.44, 95% CI [0.04-0.83]; P = 0.03). The review also revealed the positive role of CMM as an adjuvant to IVF-ET in improving pregnancy rate (PR = 1.75, 95% CI [1.25, 2.46]; P = 0.001). Conclusion TCM, with its unique way of replenishing the kidney, may provide an effective and safe alternative therapy to patients with DOR.

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    Project Supported:
    National Natural Science Foundation of China (81273791)

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