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Archive > Volume 1 Issue 1 > 2009,1(1):1-28. DOI:10.3969/j.issn.1674-6384.年份.期.第幾篇文章 Prev Next

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Challenges in Research and Development of Traditional Chinese Medicines

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    摘要:
    綜述了中藥的發(fā)展歷程以及發(fā)展過程中面臨的挑戰(zhàn)。中藥的研發(fā)是開發(fā)新藥的重要途徑。自1949年以來，大約有140種新藥被通過，其中80種直接過間接的來源于藥用植物。傳統(tǒng)中藥的發(fā)展面臨以下四個(gè)挑戰(zhàn)：（1）評價(jià)藥效、藥理活性以及機(jī)理，確定物質(zhì)基礎(chǔ)；（2）傳統(tǒng)中藥的安全性和可控性尋找新的方法；（3）加快從中藥中開發(fā)新藥的進(jìn)程；（4）將國際規(guī)范應(yīng)用于傳統(tǒng)中藥的研發(fā)中。

    Abstract:
    This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new “-omics” techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.

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