max, tmax, and AUC between acupoints administration and nonacupoints administration. Conclusion Acupoints administration resulted in a more obvious increase in bioavailability of sinapine thiocyanate, tetrahydropalmatine, 6-gingerol, and asarinin than nonacupoints administration."/>

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Archive > Volume 7 Issue 4 > 2015,7(4):365-370. DOI:10.1016/S1674-6384(15)60065-X Prev Next

Original articles

Simultaneous Determination of Four Substances in Plasma and Dermal Microdialysates of Guinea Pig after Different Acupoints Administration of Fufang Baijiezi Gel

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    Abstract:
    Objective To study the pharmacokinetic properties of Fufang Baijiezi Gel(FBG) after different acupoints administration. Methods Sinapine thiocyanate, tetrahydro-palmatine, 6-gingerol, and asarinin, which were four substances of FBG, were determined by a sensitive liquid chromatography tandem mass spectrometry method(LC-MS) both in plasma and dermal microdialysates of guinea pig simultaneously. Microdialysates were separated on an Ultimate® XB-Phenyl analytical column(150 mm×2.1 mm, 5μm) and detected by electrospray ionization(ESI) in selected ion monitoring(SIM) mode. The method was validated in terms of selectivity, linearity, sensitivity, and recovery. Result A significant difference was observed in main pharmacokinetic parameters of Cmax, tmax, and AUC between acupoints administration and nonacupoints administration. Conclusion Acupoints administration resulted in a more obvious increase in bioavailability of sinapine thiocyanate, tetrahydropalmatine, 6-gingerol, and asarinin than nonacupoints administration.

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